Type of Document	MD Thesis
Author	Mazzeo, Maria
Author's Email Address	maria.mazzeo@yale.edu
URN	etd-08212007-124014
Title	The Role of Bone Marrow Derived Cells in a Model of Hepatic Regeneration
Degree	MD
Department	Medicine
Advisory Committee	Advisor Name Title Diane Krause Committee Chair
Keywords	mice hepatocytes bone marrow transplantation gastroenterology liver disease
Date of Defense	0000-00-00
Availability	restricted
Abstract To examine the relationship between liver injury and the appearance of bone marrow derived hepatic cells we performed sex-mismatched bone marrow transplants in mice, with subsequent liver injury. Co-labeling for a marker of donor bone marrow origin and a marker of liver epithelial phenotype allowed us to identify rare marrow-derived hepatocytes at various time points following liver damage. The number of marrow-derived hepatocytes was low, however, and did not allow us to determine if liver-specific injury upregulated this process from baseline. We conclude that while marrow-derived hepatocytes are found, the low level of occurrence in this study makes it impossible to draw a clear temporal relationship between liver damage, recovery and the appearance of donor-derived cells. In addition, we cannot say whether liver-specific damage upregulates this phenomenon.
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