Type of Document	MD Thesis
Author	Abramowitz, Steven David
URN	etd-03062009-124646
Title	Comparison of Four Different Embolic Materials For Uterine Artery Embolization In Post-Procedure MRI Enhancement
Degree	MD
Department	Radiology
Advisory Committee	Advisor Name Title Michael Tal Committee Chair
Keywords	leiomyoma magnetic resonance imaging uterine artery embolization polyvinyl alcohol therapeutic embolization
Date of Defense	0000-00-00
Availability	restricted
Abstract The aim of this study was to assess embolic agent equivalency in uterine artery embolization (UAE) using post-procedure MRI enhancement of uterine fibroids in patients embolized using Embosphere Microspheres, (EM) Contour SE spheres (CSE), Poly-Vinyl Alcohol particles (PVA) and Bead Block spheres (BB). A total of 84 women with 6-month MRI follow-up constituted this retrospective study. Within this group, 25 women were treated with PVA, 23 were treated with CSE, 19 were treated with EM and 17 were treated with BB. Pre- and post-procedure MRI exams were analyzed for the total number of fibroids present in the uterus of each patient and the percentage individual fibroid enhancement of each fibroid was scored in quartile intervals. The overall percentage change in enhancement was then calculated for each patient. Bivariate analysis using Generalized Linear Modeling and one-way ANOVA was used to assess differences in infarction by different embolic materials. Of patients treated with PVA and EM, there was a mean reduction in enhancement by 76.60% and 83.07%, respectively, compared to a mean reduction of 52.53% and 49.78% in patients treated with CSE and BB, respectively. There was a statistically significant difference between CSE or BB and EM or PVA. Patients treated with BB and CSE demonstrate a reduced degree of infarction on follow-up MRI than those patients treated with PVA or EM.
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